| Autor: |
Srividhya, Swaminathan, Katie E, Lineburg, Archana, Panikkar, Jyothy, Raju, Lawton D, Murdolo, Christopher, Szeto, Pauline, Crooks, Laetitia, Le Texier, Sweera, Rehan, Michael J, Dewar-Oldis, Peter J, Barnard, George R, Ambalathingal, Michelle A, Neller, Kirsty R, Short, Stephanie, Gras, Rajiv, Khanna, Corey, Smith |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature communications. 13(1) |
| ISSN: |
2041-1723 |
| Popis: |
The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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