| Autor: |
M N, Vipond, S A, Whawell, D M, Scott-Coombes, J N, Thompson, H A, Dudley |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Annals of the Royal College of Surgeons of England. 76(6) |
| ISSN: |
0035-8843 |
| Popis: |
The deposition of fibrin in the peritoneal cavity leads to fibrous adhesion formation. Recombinant tissue plasminogen activator (rtPA), delivered locally, was investigated as a method of preventing adhesion formation. Six standardised areas of peritoneal ischaemia were formed in each of 36 male Wistar rats randomised to three intraperitoneal treatments: (A) no treatment control; (B) carboxymethylcellulose gel; (C) rtPA-carboxymethylcellulose gel combination. At 1 week all animals underwent relaparotomy and the number of ischaemic sites with an adhesion counted by an independent observer. rtPA-treated animals formed fewer adhesions compared with gel alone or controls (median number of adhesions 1.5 versus 2.5 versus 5, P < 0.001, ANOVA). Intraperitoneal rtPA in a slow-release formulation is able to reduce adhesion formation significantly in an animal model and may prove to have clinical benefit. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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