| Autor: |
Takehiko, Tsumura, Hiroo, Matsuo, Takanori, Maruo, Hisato, Kawakami, Kiyoaki, Hatano, Sumio, Saito, Norihiro, Nishijima, Masato, Nakatsuji, Atsuyuki, Ikeda, Hiroki, Nishikawa, Ryuichi, Kita, Yoshihiro, Okabe, Toru, Kimura, Ryoichi, Amitani, Yukio, Osaki |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 36(5) |
| ISSN: |
0385-0684 |
| Popis: |
Gemcitabine is an anti-cancer drug known to be safe and effective for pancreatic or biliary tract cancers, but lung injury is also known to be a rare side effect that sometimes becomes severe. Here we report seven cases of lung injury during gemcitabine treatment. Drug-induced lung injury was suspected in all cases. The male: female ratio was 5:2, and the average patient age was 71. Four had pancreatic cancers and three had biliary tract cancers. Gemcitabine had been administered an average 5.9 times at a dose of 1,141 mg. Patients showed a diffuse or patchy shadow mainly in the lower lung on computed tomography examination. Grades of adverse events were greater than 3 in all cases. Three patients died of the lung injury. Five cases had pulmonary emphysema, 2 had metastatic lung tumor as underlying pulmonary lesions, and these were assumed to have been important risk factors for drug-induced interstitial lung injury during gemcitabine treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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