| Autor: |
R M, Welsh, P L, Dundon, E E, Eynon, J O, Brubaker, G C, Koo, C L, O'Donnell |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Natural immunity and cell growth regulation. 9(2) |
| ISSN: |
0254-7600 |
| Popis: |
A monoclonal antibody (NK 1.1) to mouse natural killer (NK) cells selectively depleted NK cell activity in virus-infected mice without significantly depressing other immune functions, including the development of virus-specific cytotoxic T cells. NK cell depletion with this antibody resulted in markedly enhanced plaque-forming unit titers of some (murine cytomegalo, Pichinde) but not other (mouse hepatitis, lymphocytic choriomeningitis) viruses. This confirms that NK cells do play a role in regulating certain infections and shows that this antibody provides a convenient tool for examining the role of NK cells in viral infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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