Use of mitoxantrone-based combination chemotherapy regimens as first-line treatment for advanced breast cancer

Autor:	W R, Bezwoda, C S, Hesdorffer, R D, Dansey
Rok vydání:	1987
Předmět:	Methotrexate Antineoplastic Combined Chemotherapy Protocols Humans Breast Neoplasms Female Fluorouracil Middle Aged Mitoxantrone Neoplasm Metastasis Cyclophosphamide Drug Administration Schedule
Zdroj:	South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 72(7)
ISSN:	0256-9574
Popis:	Three first-line combination chemotherapy regimens which included mitoxantrone were studied for the treatment of advanced breast cancer. The first combination, consisting of methotrexate, mitoxantrone (Novantrone) and 5-fluoro-uracil (MNF), gave a response rate of 17/48 (35%). Cyclophosphamide + mitoxantrone (CN) gave a response rate of 20/31 (64%) while cyclophosphamide + mitoxantrone + vincristine (CNV) gave a response rate of 28/39 (72%). The response durations for the three regimens were 6 months for MNF, 7.5 months for CN and 11.5 months for CNV. The regimens were well tolerated with an approximately equal frequency of side-effects. Cardiotoxicity was infrequent, occurring in only 2 patients out of 118 studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2274f5b8232264f061b5c6cd754db4b2 https://pubmed.ncbi.nlm.nih.gov/3660150 Zobrazit plný text záznamu