| Autor: |
Danuta, Szkutnik-Fiedler, Hanna, Billert, Edmund, Grzeskowiak, Michal, Gaca, Pawel, Panienski, Magdalena, Borowicz, Grzegorz, Breborowicz |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Neuro endocrinology letters. 33(7) |
| ISSN: |
0172-780X |
| Popis: |
Systemic β-endorphin, an endogenous opioid and stress hormone, has been demonstrated to correlate with the postoperative pain intensity, however its putative role as a postoperative pain biomarker has not been cleared.Thirty patients scheduled for elective hysterectomy were included into the study. Postoperative pain was assessed by a numeric rating scale from 0 to 10. Plasma morphine concentrations were determined using high performance liquid chromatography with UV detection. Plasma β-endorphin concentrations were measured by a radioimmunoassay.Administration of morphine in intravenous infusion turned out to be a markedly better method of morphine administration up to 4th hour postoperatively regarding both drug concentration and pain rating. A significant correlation between systemic β-endorphin concentration and pain rating at the 4th postoperative hour was found. No association between morphine and β-endorphin concentrations was detected.Systemic β-endorphin is not an appropriate pain marker in postoperative gynaecologic patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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