[Overexpression of miR-382-5p Mediated Downregulation of PTEN on Malignant Biological Behavior of Human Glioma U251 Cells]

Autor: Shu-Peng, Zhao, Ying-Hua, Ji, Qing-Kai, Guan, Ji-Wei, Ma, Cai-Ling, Jin, Xiang-Yang, Wang, Xin-Li, Zhao
Rok vydání: 2020
Předmět:
Zdroj: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 51(5)
ISSN: 1672-173X
Popis: To investigate the effect of overexpression of miR-382-5p overexpression on malignant biological behavior of human glioma U251 cells.U251 cells were transfected with miR-382-5pmimic. Then miR-382-5p andResults showed that miR-382-5p directly targeted PTEN. Compared with the control group, miR-382-5p andOverexpression of miR-382-5p mediates the downregulation of PTEN expression, causing the inhibition of the proliferation, invasion, growth and EMT of U251 glioma cells.
Databáze: OpenAIRE