A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28

Autor:	B C, Hamel, H, Kremer, E, Wesby-van Swaay, B, van den Helm, A P, Smits, B A, Oostra, H H, Ropers, E C, Mariman
Rok vydání:	1996
Předmět:	Male X Chromosome Genetic Linkage Intellectual Disability Chromosome Mapping Humans Female Lod Score Pedigree
Zdroj:	American journal of medical genetics. 64(1)
ISSN:	0148-7299
Popis:	We report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). Two point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at theta = 0.0 and marker DXS1108 in Xq28 with a lod score of 3.82 at theta = 0.0. Multipoint linkage analysis showed that the odds for a location of the gene in Xq28 vs Xq21.33 are 100:1. This is the fourth family with non-specific X-linked mental retardation with Xq28-qter as the most likely gene localization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::223318bc2ae225c32abe328c09b827f7 https://pubmed.ncbi.nlm.nih.gov/8826463 Zobrazit plný text záznamu Plný text