| Autor: |
R L, Bolhuis, C H, Lamers, S H, Goey, A M, Eggermont, J B, Trimbos, G, Stoter, A, Lanzavecchia, E, di Re, S, Miotti, F, Raspagliesi |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
International journal of cancer. Supplement = Journal international du cancer. Supplement. 7 |
| ISSN: |
0898-6924 |
| Popis: |
A bispecific monoclonal antibody (bs-MAb) (OC/TR) was produced in large quantities for the intraperitoneal (i.p.) treatment of ovarian cancer. The bs-MAb recognizes the folate-binding protein on ovarian cancer cells on the one hand and the CD3 activation site on T lymphocytes on the other. T lymphocytes were expanded ex vivo, targeted with OC/TR in vitro and administered to the i.p. cavity in the presence of soluble OC/TR. All patients developed human anti-mouse-antibodies (HAMA). In the Dutch study, 2 complete remissions (CR) were seen, 2 partial regressions (PR), I stable disease (SD) and I progressive disease (PD). In the Italian study 3 CR, I PR, I SD and 2 PD were seen. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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