| Autor: |
J, Luo, J, Cheung, E M, Yevich, J P, Clark, J, Tsai, P, Lapresca, R P, Ubillas, D M, Fort, T J, Carlson, R F, Hector, S R, King, C D, Mendez, S D, Jolad, G M, Reaven |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
The Journal of pharmacology and experimental therapeutics. 288(2) |
| ISSN: |
0022-3565 |
| Popis: |
Using an ethnomedical-based drug discovery program, two previously unknown compounds (SP-18904 and SP-18905) from Pycnanthus angolensis were isolated that lower glucose concentrations in mouse models of type 2 diabetes. SP-18904 and SP-18905 are terpenoid-type quinones that significantly lowered plasma glucose concentration (p.05) when given orally to either ob/ob or db/db mice, both of which are hyperglycemic and hyperinsulinemic. The antihyperglycemic actions of SP-18904 and SP-18905 were associated with significant decreases in plasma insulin concentrations (p.05), suggesting that both compounds lowered glucose by enhancing insulin-mediated glucose uptake. This was supported by the insulin suppression test in ob/ob mice. Studies in hyperglycemic, insulin-deficient mice and in vitro experiments on 3T3-L1 adipocytes further supported this conclusion. As such, these two terpenoid-type quinones represent a new class of compounds of potential use in the treatment of type 2 diabetes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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