A randomized trial of adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 versus standard therapy in the postoperative treatment of resected nonsmall cell lung carcinoma
| Autor: | G B, Ratto, P, Zino, S, Mirabelli, P, Minuti, R, Aquilina, G, Fantino, E, Spessa, M, Ponte, P, Bruzzi, G, Melioli |
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| Rok vydání: | 1996 |
| Předmět: |
Postoperative Care
Lung Neoplasms Neoplasm Residual Injections Subcutaneous Antineoplastic Agents Middle Aged Combined Modality Therapy Immunotherapy Adoptive Survival Rate Lymphocytes Tumor-Infiltrating Treatment Outcome Carcinoma Non-Small-Cell Lung Multivariate Analysis Humans Interleukin-2 Neoplasm Recurrence Local Infusions Intravenous Pneumonectomy Follow-Up Studies Neoplasm Staging |
| Zdroj: | Cancer. 78(2) |
| ISSN: | 0008-543X |
| Popis: | A previous pilot study from our group suggested that: (1) adoptive immunotherapy (A1) with tumor-infiltrating lymphocytes (TIL) and recombinant interleukin-2 (rIL-2) may be applied with safety to more than 80% of the patients who had surgery for Stage III nonsmall cell lung carcinoma (NSCLC); and (2) AI could be useful in patients with locally advanced disease. The present randomized study was planned to assess the efficacy of AI in the postoperative treatment of Stage II, IIIa, or IIIb NSCLC:TIL were expanded in vitro from tissue samples obtained from the surgically removed specimens of 131 patients. Eighteen cultures yielded no growth of TIL. The remaining 113 patients were stratified according to disease stage and randomized to receive AI or standard chemoradiotherapy. TIL were infused intravenously 6 to 8 weeks after surgery, rIL-2 was administered subcutaneously at escalating doses for 2 weeks, and then at reduced doses for 2 weeks and then for 2 to 3 months.Three-year survival was significantly better (P0.05) for patients who underwent AI than for controls. AI was of no benefit to patients with Stage II NSCLC, potentially useful to patients with Stage IIIa NSCLC (P = 0.06), and significantly advantageous to patients with Stage IIIb (T4) NSCLC (P0.01). For patients with Stage III NSCLC, local relapse (but not distant relapse) was significantly reduced following AI (P0.05).AI should be considered when designing future adjuvant therapy protocols for the treatment of NSCLC |
| Databáze: | OpenAIRE |
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