| Autor: |
Brigid A, Adviento, Elizabeth A, Regan, Barry J, Make, MeiLan K, Han, Marilyn G, Foreman, Anand S, Iyer, Surya P, Bhatt, Victor, Kim, Jessica, Bon, Xavier, Soler, Gregory L, Kinney, Nicola A, Hanania, Katherine E, Lowe, Kristen E, Holm, Abebaw M, Yohannes, Gen, Shinozaki, Karin F, Hoth, Jess G, Fiedorowicz |
| Rok vydání: |
2022 |
| Zdroj: |
Chest. |
| ISSN: |
1931-3543 |
| Popis: |
Studies have shown that chronic obstructive pulmonary disease (COPD) and smoking are associated with increased suicide risk. To date there are no prospective studies examining suicide risk among smokers along a spectrum of pulmonary disease ranging from completely normal spirometry to severe COPD.Which clinical variables predict death by suicide or overdose of indeterminate intent in a large cohort of heavy smokers within the COPDGene study?We studied data from 9,930 participants involved in COPDGene, a multisite, prospective cohort study of current and former smokers. Primary cause of adjudicated deaths was identified using death certificates, family reports, and medical records. We examined time to death by suicide/overdose as the primary outcome in Cox regression adjusted for age, sex, race, BMI, pack-years, current smoking status, airflow limitation (%predicted FEVThe cohort was 47% female, 33% Black (67% White), had a mean (SD) age of 59.6 (9.0) years, and mean FEVIn this well-characterized cohort of current and former smokers with and without COPD, we identified risk factors for suicide/overdose that emphasize the subjective experience of illness over objective assessments of lung function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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