| Autor: |
M, Duran, L, Bruinvis, D, Ketting, L, Dorland |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Padiatrie und Padologie. 28(1) |
| ISSN: |
0030-9338 |
| Popis: |
Inherited defects of mitochondrial beta-oxidation of fatty acids lead to hypoketotic hypoglycemia during prolonged fasting. Affected patients may present with episodes of a Reye-like illness or even sudden child death. The number of currently detected patients with medium-chain acyl-CoA dehydrogenase deficiency--the most common disease in this area--is indicative of a high frequency, possibly comparable to that of phenylketonuria. A comprehensive system of biochemical analyses is described, which enables the differential diagnosis of the various defects. An indispensable part of the diagnostic system is the gas chromatographic/mass spectrometric analysis of plasma and urinary organic acids. A correct diagnosis is a prerequisite for the installment of specific treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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