Invariant NKT Cell Activation Is Potentiated by Homotypic
| Autor: | Yuriy, Baglaenko, Mayra, Cruz Tleugabulova, Eric, Gracey, Nafiseh, Talaei, Kieran Patricia, Manion, Nan-Hua, Chang, Dario Michael, Ferri, Thierry, Mallevaey, Joan E, Wither |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cell Differentiation
Dendritic Cells Lymphocyte Activation Mice Inbred C57BL Mice Gene Expression Regulation Signaling Lymphocytic Activation Molecule Family Member 1 Signaling Lymphocytic Activation Molecule Family Animals Antigens Ly Cytokines Humans Natural Killer T-Cells Antigens CD1d RNA Small Interfering |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 198(10) |
| ISSN: | 1550-6606 |
| Popis: | Invariant NKT (iNKT) cells are innate lymphocytes that respond to glycolipids presented by the MHC class Ib molecule CD1d and are rapidly activated to produce large quantities of cytokines and chemokines. iNKT cell development uniquely depends on interactions between double-positive thymocytes that provide key homotypic interactions between signaling lymphocyte activation molecule (SLAM) family members. However, the role of SLAM receptors in the differentiation of iNKT cell effector subsets and activation has not been explored. In this article, we show that C57BL/6 mice containing the New Zealand Black |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|