The pharmacology of recombinant hirudin, a new anticoagulant

Autor: B H, Meyer, H G, Luus, F O, Müller, P N, Badenhorst, H J, Röthig
Rok vydání: 1990
Předmět:
Zdroj: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 78(5)
ISSN: 0256-9574
Popis: A new anticoagulant, recombinant hirudin, was given to healthy volunteers (5 per test dose) in single intravenous doses of 0.01, 0.02, 0.04, 0.07 and 0.1 mg/kg to study its anticoagulant effects, how it was tolerated and its pharmacokinetics. Hirudin proved to be a potent anticoagulant with important effects on thrombin (increase in thrombin time and partial thromboplastin time). The maximum pharmacodynamic effect was achieved with the 0.07 mg/kg dose, and upwards. All doses of the compound were tolerated without side-effects. The mean elimination half-life is about 1 hour. Mean total clearance and volume of distribution are approximately 190 ml/min and 14 l, respectively. Hirudin obeys first-order pharmacokinetics.
Databáze: OpenAIRE