| Autor: |
Lu-xin, Na, Xin, Liu, Zhuo-ming, Meng, Zhu, Guan, Li-he, Zhang, Zhen-jun, Yang |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Yao xue xue bao = Acta pharmaceutica Sinica. 50(1) |
| ISSN: |
0513-4870 |
| Popis: |
Photoaffinity labeling is widely applied to demonstrate targets of small molecule ligands. In this paper, biotin photoaffinity labeled molecule with propargyl group 1 has been designed and synthesized, followed it's labeling of N2-acetyl-2'-O-propargyl guanosine 9 by "click chemistry". This technology presents delight development potential in labeling of second messenger cyclic nucleotide, antisense oligonucleotide or siRNA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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