Nicotine induces brain CYP enzymes: relevance to Parkinson's disease

Autor:	S, Miksys, R F, Tyndale
Rok vydání:	2006
Předmět:	Cytochrome P-450 CYP2B6 Nicotine Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System Enzyme Induction Animals Brain Humans Cytochrome P-450 CYP2E1 Oxidoreductases N-Demethylating Parkinson Disease Aryl Hydrocarbon Hydroxylases Nicotinic Agonists
Zdroj:	Journal of neural transmission. Supplementum. (70)
ISSN:	0303-6995
Popis:	Brain expression of cytochromes P450 2B6, 2D6 and 2E1 is higher in smokers, and is induced by nicotine in animals. These enzymes can metabolize many of the neurotoxins associated with Parkinson's disease. Since smoking is known to be protective against Parkinson's disease, we hypothesise that nicotine-induced elevation of brain CYPs in smokers may contribute to neuroprotection against Parkinson's disease. This supports the therapeutic use of nicotine to delay the progress of this disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2153c0936db59df97f61deebc306aa7e https://pubmed.ncbi.nlm.nih.gov/17017527 Zobrazit plný text záznamu