[Antiradical activity and membranotropic action of cardio- and vasotropic compounds of varying chemical nature]
| Autor: | I V, Nizhenkovskaia, Iu I, Gubskiĭ, I S, Checkman, A G, Goriushko, N A, Gorchakova, L G, Sachenko |
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| Rok vydání: | 1998 |
| Předmět: |
Cardiotonic Agents
Ion Transport Nifedipine Myocardium Vasodilator Agents Lipid Bilayers Free Radical Scavengers 3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester Calcium Channel Blockers Calcium Channel Agonists Structure-Activity Relationship Verapamil Dobutamine Calcium |
| Zdroj: | Ukrainskii biokhimicheskii zhurnal (1. 70(4) |
| ISSN: | 0201-8470 |
| Popis: | Antiradical activity and ability to interaction with phosphatidylcholine bilayer of the physiological active compounds (PhAC), concerning the classes of phenylalkilamines (dobutamine, verapamil), dihydro pyridines (BAY-K-4688, nifedipine), analogues of crown ether (carbicyle, diol) was studied. By means of the method of microcalorimetry and spectrophotometry it was shown the complexing ability PhAC with the phospholipid bilayer of the model membrane. It was stated the simbasity in the changes of the thermal effect of the compounds with the negative inotropic activity during its reaction with phosphatidylcholine bilayer and antiradical activity. That show on the presence of antiradical component in the mechanism that compounds' action. |
| Databáze: | OpenAIRE |
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