Active infective endocarditis: Clinical characteristics and factors related to hospital mortality
| Autor: | Carlo, Rostagno, Gabriele, Rosso, Francesco, Puggelli, Sandro, Gelsomino, Lucio, Braconi, Gian Franco, Montesi, Stefano, Romagnoli, Pier Luigi, Stefano, Gian Franco, Gensini |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pacemaker Artificial Chi-Square Distribution Prosthesis-Related Infections Time Factors Endocarditis Middle Aged Heart Valves Risk Assessment Treatment Outcome Italy Risk Factors Heart Valve Prosthesis Humans Female Hospital Mortality Prospective Studies Cardiac Surgical Procedures Echocardiography Transesophageal Aged |
| Zdroj: | Cardiology journal. 17(6) |
| ISSN: | 1898-018X |
| Popis: | Little information exists on the clinical characteristics and factors related to hospital mortality in patients with active infective endocarditis referred for surgery.Between January 1, 2003 and December 31, 2006, 86 patients (56 males, 30 females, mean age 59.2 years) with active infective endocarditis were referred to our Department (2.8% of overall hospitalizations). The relation of several clinical, laboratory and echocardiographic findings at admission with hospital mortality was evaluated.A native valve (NVE) was involved in 50/86; the other 30 had a prosthetic valve endocarditis (PVE). Six had pacemaker endocarditis. The aortic valve was involved more frequently than the mitral valve, both in NVE and PVE. The tricuspid valve was involved in four drug addicts; 51% of patients were in NYHA class III-IV. Staphylococci and streptococci were isolated in 69% of patients (39% vs 30%). Blood cultures were negative in 24%. Overall hospital mortality has been 11.6%. Two patients died before surgery, eight in the perioperative period. Hospital mortality was closely related to age, clinical and laboratory evidence of advanced septic condition (temperature38°C, leukocytosis and creatinine2.0 mg/dL) and hemodynamic impairment.Active infective endocarditis is a significant cause of referral to heart surgery departments and hospital mortality is still10%. Clinical and laboratory parameters easily available at admission suggest that severe sepsis and/or hemodynamic impairment may be helpful in predicting the clinical outcome in this group of high risk patients. |
| Databáze: | OpenAIRE |
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