4-Tesla 1H MR spectroscopy in patients with temporal lobe epilepsy
| Autor: | P, Schüler, H, Stefan, G, Schuierer, D, Hentschel, R, Ladebeck, R, Wittig, W, Huk, B, Neundörfer |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Aspartic Acid Magnetic Resonance Spectroscopy Adolescent Phosphocreatine Phosphorylcholine Glutamic Acid Middle Aged Creatine Temporal Lobe Choline Epilepsy Temporal Lobe Glutamates Reference Values Lactates Humans Female Epilepsies Partial Epilepsy Tonic-Clonic Lactic Acid Energy Metabolism |
| Zdroj: | Der Nervenarzt. 62(12) |
| ISSN: | 0028-2804 |
| Popis: | 7 patients with drug-resistant temporal lobe epilepsy (TLE) and localized EEG-focus were investigated with a 4 Tesla whole body MR-scanner. Proton (1H) magnetic resonance (MR) spectra were analyzed quantitatively and compared to the healthy side. MRS allowed the differentiation of the following metabolites in 5 patients: N-acetyl-aspartate (NAA), creatine and phosphocreatine, phosphorylcholine and glycerophosphorylcholine, beta- and gamma-glutamate (GLU). To compare the results with those of an already evaluated normal population, these metabolites were measured also in parietal region. The standard deviation was 42-46% in the patients. Unfortunately, in the temporal region, the field homogeneity was worse than parietal and thus the spectral analysis less distinct especially for GLU with a standard deviation of 45% for NAA and 66% for GLU on the healthy side. Thus, no significant findings were seen on focus side. There was only a tendency to an elevation of glutamate and a reduction of N-acetyl-aspartate. |
| Databáze: | OpenAIRE |
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