| Autor: |
Tianling, Wei, Kyriakos, Orfanidis, Ning, Xu, Peter, Janson, Mona, Ståhle, Andor, Pivarcsi, Enikö, Sonkoly |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Experimental dermatology. 19(9) |
| ISSN: |
1600-0625 |
| Popis: |
MicroRNAs are small, non-coding RNAs that regulate gene expression post-transcriptionally and play important roles in various biological processes. We previously identified miR-203 as a skin- and keratinocyte-specific microRNA. Moreover, miR-203 has been implicated in repressing 'stemness' in epidermal progenitors. Here, we investigate the expression of miR-203 and two of its targets, p63 and suppressor of cytokine signalling-3, during human skin morphogenesis. MiR-203 in situ hybridization was performed on sections of human foetal skin ranging from 14 to 22 weeks' gestation and adult skin. MiR-203 was barely detectable at 14 weeks. Its expression became prominent from week 17 and was most pronounced in the suprabasal layers of the epidermis, while p63 and SOCS-3 were preferentially expressed in the basal layer. Differentiation markers such as involucrin and filaggrin were expressed mainly in the suprabasal layers of epidermis, similar to miR-203. Our results support the involvement of miR-203 in skin morphogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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