Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
| Autor: | Ji, Zhang, Cyrla, Hoffert, Huy Khang, Vu, Thierry, Groblewski, Sultan, Ahmad, Dajan, O'Donnell |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Time Factors Receptors Drug Freund's Adjuvant Gene Expression Pain Avian Proteins Rats Sprague-Dawley Receptor Cannabinoid CB2 Antigens CD Antigens Neoplasm Glial Fibrillary Acidic Protein Animals RNA Messenger Receptors Cannabinoid In Situ Hybridization Spinal Cord Injuries Inflammation Membrane Glycoproteins CD11 Antigens Membrane Proteins Blood Proteins Ectodysplasins Immunohistochemistry Rats Disease Models Animal Antigens Surface Basigin Microglia Sciatic Neuropathy |
| Zdroj: | The European journal of neuroscience. 17(12) |
| ISSN: | 0953-816X |
| Popis: | Cannabinoids have been considered for some time as potent therapeutic agents in chronic pain management. Central and systemic administration of natural, synthetic and endogenous cannabinoids produce antinociceptive and antihyperalgesic effects in both acute and chronic animal pain models. Although much of the existing data suggest that the analgesic effects of cannabinoids are mediated via neuronal CB1 receptors, there is increasing evidence to support a role for peripheral CB2 receptors, which are expressed preferentially on immune cells. As yet, little is known about the central contribution of CB2 in neuropathic pain states. We report here that chronic pain models associated with peripheral nerve injury, but not peripheral inflammation, induce CB2 receptor expression in a highly restricted and specific manner within the lumbar spinal cord. Moreover, the appearance of CB2 expression coincides with the appearance of activated microglia. |
| Databáze: | OpenAIRE |
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