Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence

Autor:	Abdel-Gawad S, Shalkami, Emad H M, Hassanein, Ahmed M, Sayed, Wafaa R, Mohamed, Marwa M, Khalaf, Ramadan A M, Hemeida
Rok vydání:	2021
Předmět:	Molecular Docking Simulation Oxidative Stress Methotrexate Berberine NF-E2-Related Factor 2 Phytochemicals NF-kappa B Animals Humans Umbelliferones Rats Signal Transduction
Zdroj:	Environmental science and pollution research internationalReferences. 28(47)
ISSN:	1614-7499
Popis:	Chemotherapeutic drugs are used effectively to manage wide types of malignancies, but their therapeutic use is limited due to their associated hepatic intoxication. The current study sheds light on the effect of phytochemicals berberine (BBR) and umbelliferone (UMB) on methotrexate (MTX)-induced hepatic intoxication. Forty-eight rats were allocated to normal, BBR (50 mg/kg orally for 10 days), UMB (30 mg/kg orally for 10 days), MTX (20 mg/kg at the 5th day), BBR+MTX, and UMB+MTX. With regard to MTX, the results of this investigation reveal potent amelioration of MTX hepatotoxicity by BBR and UMB through reduction of the elevated serum levels of ALT, ALP, AST, and LDH confirmed by the attenuation of histopathological abrasion in liver tissues. BBR and UMB markedly restored antioxidant status. More importantly, BBR resulted in reducing P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::20cc25856b0243703469acdd741b08a3 https://pubmed.ncbi.nlm.nih.gov/34258700 Zobrazit plný text záznamu Full text from SpringerLink