Antitumor activity of a piperidine phospholipid
| Autor: | W J, Houlihan, M L, Lee, P G, Munder, D A, Handley, G A, Nemecek, C S, Jaeggi, C W, Winslow |
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| Rok vydání: | 1994 |
| Předmět: |
Mice
Inbred BALB C Cell Survival Fibrosarcoma Macrophages Phospholipid Ethers Antineoplastic Agents Receptors Cell Surface Platelet Membrane Glycoproteins Fibroblasts Binding Competitive Receptors G-Protein-Coupled Lethal Dose 50 Mice Inbred C57BL Mice Piperidines Tumor Cells Cultured Animals Humans Receptors Platelet-Derived Growth Factor Sarcoma Experimental Platelet Activating Factor Neoplasm Transplantation Platelet Aggregation Inhibitors |
| Zdroj: | Arzneimittel-Forschung. 44(12) |
| ISSN: | 0004-4172 |
| Popis: | A piperidine phospholipid ((+/-)-2-[hydroxy] [1-octadecyloxycarbonylpiperidin-3-yl]methoxy-phosphinyl] oxy]-N,N,N, trimethylethaniminium hydroxide inner salt, SDZ 62-826) has been prepared that exhibited weak direct cytotoxicity and strong macrophage-induced cytotoxicity in vitro against a variety of murine and one human tumor cell lines. This compound was found to be as effective as ET-18-OCH3 and SRI 62-834, phospholipids with both strong direct and macrophage-induced cytotoxicity, in increasing survivors and reducing tumor volume when given either orally or intravenously in the mouse MethA fibrosarcoma model. These findings suggest that the macrophage-induced cytotoxicity exhibited by ET-18-OCH3 and other phospholipids may play an important role in this tumor model. |
| Databáze: | OpenAIRE |
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