Reducing adverse effects of proton pump inhibitors
| Autor: | Paul W, Ament, Daniel B, Dicola, Mary E, James |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Diarrhea
Ticlopidine Anemia Iron-Deficiency Critical Care Clostridioides difficile Hip Fractures Myocardial Infarction Proton Pump Inhibitors Pneumonia Clopidogrel Recurrence Risk Factors Stress Physiological Gastroesophageal Reflux Humans Drug Interactions Stomach Ulcer Gastrointestinal Hemorrhage Enterocolitis Pseudomembranous Platelet Aggregation Inhibitors Ulcer |
| Zdroj: | American family physician. 86(1) |
| ISSN: | 1532-0650 |
| Popis: | Proton pump inhibitors effectively treat gastroesophageal reflux disease, erosive esophagitis, duodenal ulcers, and pathologic hypersecretory conditions. Proton pump inhibitors cause few adverse effects with short-term use; however, long-term use has been scrutinized for appropriateness, drug-drug interactions, and the potential for adverse effects (e.g., hip fractures, cardiac events, iron deficiency, Clostridium difficile infection, pneumonia). Adults 65 years and older are more vulnerable to these adverse effects because of the higher prevalence of chronic diseases in this population. Proton pump inhibitors administered for stress ulcer prophylaxis should be discontinued after the patient is discharged from the intensive care unit unless other indications exist. |
| Databáze: | OpenAIRE |
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