| Autor: |
J J, Flanagan, B F, Rush, T F, Murphy, S, Smith, G W, Machiedo, J, Hsieh, D M, Rosa, J B, Heneghan |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Journal of medicine. 21(1-2) |
| ISSN: |
0025-7850 |
| Popis: |
In an unanesthetized "treated" model of severe hemorrhagic shock, a bacteremia originating from the animal's enteric flora was demonstrated by finding radiolabeled Escherichia coli in the blood as early as 2 hr after the onset of shock. In 50 patients admitted to our trauma unit, the observation was similar, with 56% positive blood cultures, when their mean arterial blood pressure was 80 mmHg or less. The relationship of bacterial translocation and the high post-shock mortality in our conventional (CV) animal model is being evaluated in germfree (GF) Sprague-Dawley rats. Preliminary observations in 15 GF animals showed 80% survival at 24 hr post-shock, 54% at 48 hr, and 42% at 72 hr compared with those of CV animals in previous experiments with survival at similar times of 73%, 20% and 7%, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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