A 2-year follow-up of an anti-HIV immune reaction in HIV-1 gp160-immunized healthy seronegative humans: evidence for persistent cell-mediated immunity
| Autor: | O, Picard, A, Achour, J, Bernard, A, Halbreich, B, Bizzini, V, Boyer, C, Desgranges, J M, Bertho, A, Lachgar, B, Polliotti |
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| Rok vydání: | 1992 |
| Předmět: |
AIDS Vaccines
Adult Male Immunity Cellular Vaccines Synthetic HIV Antigens Blotting Western Molecular Sequence Data Gene Products env Enzyme-Linked Immunosorbent Assay HIV Infections HIV Antibodies Middle Aged HIV Envelope Protein gp160 Neutralization Tests HIV-1 Humans Female Immunization Amino Acid Sequence Protein Precursors Immunologic Memory Follow-Up Studies |
| Zdroj: | Journal of acquired immune deficiency syndromes. 5(6) |
| ISSN: | 0894-9255 |
| Popis: | The first trial of an anti-HIV immunization, using a recombinant vaccinia virus expressing gp160 (rV) for priming and paraformaldehyde-fixed rV-infected PBLs and soluble gp 160 for boosting, clearly showed an in vitro HIV-protective immune reaction. This result led us to carry out an additional 2 year Phase I clinical trial in 25 HIV-seronegative volunteers, using HIV gp 160 antigens for immunization in four different protocols. The 2 year trial showed (a) the safety of the preparations, (b) a transient humoral immunity following each boost, and (c) a long-lasting memory T-cell response. Memory cytotoxic T-lymphocytes (CTLs) induced by gp 160 antigen with or without vaccinia vector lysed HLA class I restricted target cells expressing HIV-1 env antigens. These results are consistent with CTLs being an effective component of an AIDS vaccine to control cell-to-cell viral replication, dissemination in the organism, and subsequent evolution toward AIDS. |
| Databáze: | OpenAIRE |
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