| Autor: |
Irene M, Vavasour, Nasim, Vafai, Philippe, Beauchemin, Chironjeev, Kanjilal, Alexandru, Badalan, Elham, Shahinfard, Cornelia, Laule, David Kb, Li, Anthony, Traboulsee, Vesna, Sossi, Shannon H, Kolind, Robert L, Carruthers |
| Rok vydání: |
2022 |
| Zdroj: |
Multiple sclerosis and related disorders. 68 |
| ISSN: |
2211-0356 |
| Popis: |
MRI-based myelin water fraction (MWF) and PET-based Pittsburgh compound B (PiB) imaging both have potential to measure myelin in multiple sclerosis (MS). We characterised the differences in MWF and PiB binding in MS lesions relative to normal-appearing white matter and assessed the correlation between MWF and PiB binding in 11 MS participants and 3 healthy controls within 14 white matter regions of interest. Both PiB binding and MWF were reduced in MS lesions relative to NAWM, and a modest within subject correlation between MWF and PiB binding was found. This pilot study shows that MWF and PET-PiB provide different information about myelin loss in MS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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