Clinical trial: The effect of somatostatin vs. octreotide in preventing post-endoscopic increase in hepatic venous pressure gradient in cirrhotics with bleeding varices

Autor:	J, Vlachogiannakos, A, Kougioumtzian, C, Triantos, N, Viazis, S, Sgouros, S, Manolakopoulos, A, Saveriadis, C, Markoglou, T, Economopoulos, D G, Karamanolis
Rok vydání:	2007
Předmět:	Adult Aged 80 and over Liver Cirrhosis Male Hepatic Veins Middle Aged Esophageal and Gastric Varices Octreotide Endoscopy Gastrointestinal Double-Blind Method Recurrence Sclerotherapy Humans Female Prospective Studies Treatment Failure Gastrointestinal Hemorrhage Somatostatin Venous Pressure Aged
Zdroj:	Alimentary pharmacologytherapeutics. 26(11-12)
ISSN:	1365-2036
Popis:	Hepatic venous pressure gradient (HVPG) increases significantly after endoscopic therapy in patients with bleeding oesophageal varices, which may precipitate further haemorrhage. Whether vasoactive drugs can suppress these changes remains unknown.To investigate the efficacy of somatostatin when compared with octreotide in preventing the post-endoscopic increase in HVPG during acute bleeding and whether the changes affect outcome.Thirty-three cirrhotics with bleeding varices were randomized to receive somatostatin (n = 17) or octreotide (n = 16) under double-blind conditions, soon after their admission. HVPG measurements were performed before and immediately after endoscopic treatment.In the somatostatin group, postendotherapy HVPG values did not change significantly when compared with pre-treatment values (18.9 vs. 17.2, P = 0.092). Conversely, in the octreotide group, HVPG increased significantly after endoscopy (18.2 vs. 20.8, P = 0.003). The probability of 6-week survival without treatment failure was significantly higher in the somatostatin group (P = 0.024). Post-endoscopic HVPG value was independently associated with 6-week failure.Somatostatin, but not octreotide, effectively prevents the post-endoscopic increase in HVPG, which may be associated with low probability of treatment failure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1ffb203b994417a6b98acb0229315d4d https://pubmed.ncbi.nlm.nih.gov/17919272 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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