| Autor: |
Qi, Han, Na, Wang, Chaoying, Pan, Yue, Wang, Jianli, Sang |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Molecular microbiologyReferences. 112(3) |
| ISSN: |
1365-2958 |
| Popis: |
β-1,6-glucan is an important cell wall component of Candida albicans. Deleted mutants of the two β-1,6-glucan synthase genes KRE6 and SKN1 are viable albeit with a range of defects including slow growth. It remains unclear whether β-1,6-glucan synthesis is not required under culture conditions or compensatory mechanisms exist in C. albicans. Here, we report that depleting β-1,6-glucan synthases leads to a significant increase in cell wall chitin levels through the posttranscriptional regulation of the chitin synthase Chs3 which maintains cell viability. And depleting β-1,6-glucan synthases in chs3Δ/Δ cells results in cell death. The elevation of cell wall chitin is mediated by the activation of the PKC signaling pathway and an unknown pathway(s) involving Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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