Analysis of treatment effects on the microbial ecology of the human intestine

Autor:	Anna L, Engelbrektson, Joshua R, Korzenik, Mary Ellen, Sanders, Brian G, Clement, Gregory, Leyer, Todd R, Klaenhammer, Christopher L, Kitts
Rok vydání:	2006
Předmět:	Adult DNA Bacterial Principal Component Analysis Bacteria Probiotics DNA Fingerprinting Anti-Bacterial Agents Intestines Placebos Feces Double-Blind Method Cluster Analysis Humans Polymorphism Restriction Fragment Length
Zdroj:	FEMS microbiology ecology. 57(2)
ISSN:	0168-6496
Popis:	A large number of studies have investigated gastrointestinal microbiota and changes in the gastrointestinal community. However, a concern in these studies is how best to assess changes in gastrointestinal community structure. This paper presents two different human trials where the fecal terminal restriction fragment length polymorphism data sets were analyzed to search for treatment effects. Principle components analysis and cluster analysis based on grouped data are compared with analysis of data by subject using distance coefficients. Comparison with baseline within an individual before grouping by treatment provided a clearer indication of treatment effects than did an evaluation of data grouped before analysis. In addition, a large within-subject sample size and multiple baseline samples are necessary to accurately analyze treatment effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1fa40c8a266430595937f6726d45a3ef https://pubmed.ncbi.nlm.nih.gov/16867142 Zobrazit plný text záznamu Plný text