| Autor: |
A S, Prakash, K K, Valu, L P, Wakelin, P D, Woodgate, W A, Denny |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Anti-cancer drug design. 6(3) |
| ISSN: |
0266-9536 |
| Popis: |
The mustard derivative, bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5- [N,N-dimethylamino)methyl)aminophenyl]-1,4-benzenedicarboxamide has been synthesized from 3-acetamido-5-nitrobenzoic acid in a 6-step procedure. This compound alkylates exclusively in the minor groove of DNA, at the N3 site of adenines occurring in sequences of runs of adenines and (to a small extent) at 5'-TA and 5'-AT sites. Gel electrophoresis studies and in vitro cytotoxicity assays against repair-deficient AA8 mutant cell lines show it has a high degree of DNA interstrand cross-linking ability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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