Autor:	Marek, Brodzki, Jerzy W, Mozrzymas
Rok vydání:	2022
Předmět:	Patch-Clamp Techniques Proline Receptors GABA-A Ion Channel Gating gamma-Aminobutyric Acid
Zdroj:	Life sciences. 308
ISSN:	1879-0631
Popis:	GABAWe recorded micro- and macroscopic current responses of recombinant GABAMutations of this residue impaired macroscopic desensitization and accelerated current deactivation with P273E mutant showing greatest deviation from wild-type. Single-channel analysis revealed alterations mainly in short-lived shut times and shortening of openings, resulting in dramatic changes in intraburst open probability. Kinetic modeling indicated that βIn conclusion, we demonstrate that β
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1f92d3b8887af70a289475c893a1f071 https://pubmed.ncbi.nlm.nih.gov/36096246 Zobrazit plný text záznamu Full Text from ScienceDirect