[A Case of Intrathecal Infusion of Methotrexate and Ara-C for a Patient with Meningitis Due to Recurrent Gastric Cancer]

Autor: Takashi, Oiwa, Yasuhiro, Kurumiya, Keisuke, Mizuno, Ei, Sekoguchi, Satoshi, Kobayashi, Kiyotaka, Kawai, Muneyasu, Kiriyama, Kenta, Tominaga, Naoya, Torii, Yuu, Nakashima, Makiko, Mori, Syuta, Ikeda, Hiroki, Watanabe
Rok vydání: 2017
Předmět:
Zdroj: Gan to kagaku ryoho. Cancerchemotherapy. 44(5)
ISSN: 0385-0684
Popis: A 69-year-old woman underwent total gastrectomy for advanced gastric cancer with pyloric stenosis. She had a good postoperative course and was discharged 2 weeks after surgery. She received adjuvant chemotherapy with S-1 after discharge. One month after the initiation of the adjuvant chemotherapy, she complained of wobbling and weakness of her limbs. She stopped intake of S-1, but the symptoms did not improve. She was admitted to the hospital, but she became unconscious and had headache and blurred vision. We conducted a cerebrospinal fluid examination and made a diagnosis of meningeal carcinomatosis. After we started intrathecal infusion of methotrexate and Ara-C, referring to case reports clinical symptoms, including unconsciousness, headache, and left upper limb paralysis, improved and the CEA level in cerebrospinal fluid decreased.
Databáze: OpenAIRE