| Autor: |
K Iu, Mukhin, S V, Piliia, E Iu, Volkova, V A, Chadaev, M B, Mironov, N E, Kvaskova, A S, Petrukhin |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 107(3) |
| ISSN: |
1997-7298 |
| Popis: |
An efficacy of high dosages of piracetam in the treatment of children with Kozhevnikov epilepsy syndrome (epilepsia partialis continua) has been studied. The study included 6 patients, aged from 9 to 16 years, with diagnosis of Kozhevnikov epilepsy (KE) who received piracetam (nootropil, UCB) in mean dose of 1g/kg/day (up to 35 g/day) intravenous in drops. The treatment course was 30 days. During therapy, there was decrease of myoclonus frequency by 75% in 3 patients and its full stopping in 3 patients. Focal clonic seizures were stopped in 2 cases, their frequency decreased in 4 cases. Secondary generalized seizures did not relapse in 2 cases and there was a decrease of seizures by 50% and over in 4 remained cases. The use of nootropil led to the improvement of neurological status in 5 out of 6 patients with KE. The intensity of hemiparesis was reduced in 3 patients treated with nootropil. The improvement of cognitive functioning was observed in 5 out of 6 patients. The duration of clinical improvement was 1-2 months after infusions cessation. The study revealed the efficacy of high dosages of nootropil in combination with basic antiepileptic drugs in the treatment of Kozhevnikov epilepsy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
