| Autor: |
J R, Halpert, T L, Domanski, O, Adali, C P, Biagini, J, Cosme, E A, Dierks, E F, Johnson, J P, Jones, P, Ortiz de Montellano, R M, Philpot, O, Sibbesen, W K, Wyatt, Z, Zheng |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 26(12) |
| ISSN: |
0090-9556 |
| Popis: |
This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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