| Autor: |
I G, Bazhanova, T N, Remova, M N, Ozeretskovskaia, E I, Shmeleva, N U, Mertsalova, E E, Sukhinova, R P, Chuprinina, V F, Bulk, I E, Semina, S Ia, Koval'skaia |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (1) |
| ISSN: |
0372-9311 |
| Popis: |
The preclinical trial of a new cell-free pertussis vaccine has been carried out with a view to its comparison with whole-cell pertussis vaccine in respect of the toxic and protective properties of the preparations under experimental conditions. The whole-cell pertussis vaccine is characterized by pronounced toxic action causing leukocytosis and histamine-sensitization, produces a negative effect on the detoxifying function of the liver and possesses sensitizing activity. The cell-free pertussis vaccine has pronounced protective activity. In animal experiments the supposed immunization dose of this vaccine has proved to be nontoxic. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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