Single-cell and spatial analysis reveal interaction of FAP

Autor: Jingjing, Qi, Hongxiang, Sun, Yao, Zhang, Zhengting, Wang, Zhenzhen, Xun, Ziyi, Li, Xinyu, Ding, Rujuan, Bao, Liwen, Hong, Wenqing, Jia, Fei, Fang, Hongzhi, Liu, Lei, Chen, Jie, Zhong, Duowu, Zou, Lianxin, Liu, Leng, Han, Florent, Ginhoux, Yingbin, Liu, Youqiong, Ye, Bing, Su
Rok vydání: 2021
Předmět:
Zdroj: Nature communications. 13(1)
ISSN: 2041-1723
Popis: Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables the discovery of potential therapeutic targets. Here, we profile 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidate the potential origin and regulation of tumor-enriched cell types in CRC. We demonstrate that the tumor-specific FAP
Databáze: OpenAIRE