| Autor: |
Darrell L, Ellsworth, Kimberly A, Mamula, Heather L, Blackburn, Fionnuala A, McDyer, Gera L, Jellema, Ryan, van Laar, Nicholas S, Costantino, Renata J M, Engler, Marina N, Vernalis |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Obesity (Silver Spring, Md.). 23(6) |
| ISSN: |
1930-739X |
| Popis: |
To examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles.A prospective nonrandomized trial was conducted over 1 year in participants undergoing intensive lifestyle modification to reverse or stabilize progression of coronary artery disease. Cardiovascular risk factors, inflammatory biomarkers, and gene expression as a function of weight loss were assessed in 89 lifestyle participants and 71 retrospectively matched controls undergoing usual care.Substantial weight loss (-15.2 ± 3.8%) in lifestyle participants (n = 33) was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes (false discovery rate corrected P-value0.05 and fold-change ≥1.4). Altered molecular pathways were related to immune function and inflammatory responses involving endothelial activation. In contrast, participants losing minimal weight (-3.1 ± 2.5%, n = 32) showed only minor changes in cardiovascular risk factors and markers of inflammation and no changes in gene expression compared to non intervention controls after 1 year.Weight loss (≥10%) during lifestyle modification is associated with down-regulation of genetic pathways governing interactions between circulating immune cells and the vascular endothelium and may be required to successfully reduce CVD risk. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text