| Autor: |
Najim A, Al-Masoudi, Iman A, Al-Masoudi, Ibrahim A I, Ali, Yaseen A, Al-Soud, Bahjat, Saeed, Paolo, La Colla |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Acta pharmaceutica (Zagreb, Croatia). 56(2) |
| ISSN: |
1330-0075 |
| Popis: |
A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 was assayed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC501.6 microg mL(-1), meanwhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L(-1). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
