| Autor: |
Aleksey K, Molodtsov, Nikhil, Khatwani, Jennifer L, Vella, Kathryn A, Lewis, Yanding, Zhao, Jichang, Han, Delaney E, Sullivan, Tyler G, Searles, Nicholas K, Preiss, Tamer B, Shabaneh, Peisheng, Zhang, Aaron R, Hawkes, Brian T, Malik, Fred W, Kolling, Edward J, Usherwood, Sandra L, Wong, Joseph D, Phillips, Keisuke, Shirai, Christina V, Angeles, Shaofeng, Yan, Tyler J, Curiel, Yina H, Huang, Chao, Cheng, Mary Jo, Turk |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Immunity |
| ISSN: |
1097-4180 |
| Popis: |
The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) cells in anti-tumor responses at metastatic locations using a mouse model of melanoma-associated vitiligo. We found that the transcriptional characteristics of tumor-specific CD8+ T cells were defined by the tissue of occupancy. Parabiosis revealed that tumor-specific Trm and Tcirm compartments persisted throughout visceral organs, but Trm cells dominated lymph nodes (LNs). Single cell RNA sequencing profiles of LN Trm and skin Trm cells in LN and skin were distinct, but shared clonotypes that occupied both tissues were preferentially overwhelmingly maintained as Trm in LNs. Whereas Tcirm cells prevented melanoma growth in the lungs, Trm afforded long-lived protection against melanoma seeding in LNs. Expanded Trm populations were also present in melanoma-involved LNs from patients, and their transcriptional signature predicted better survival. Thus tumor-specific Trm cells persist in LNs, restricting metastatic cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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