| Autor: |
Jianping, Chen, Crystal Y Q, Du, Kelly Y C, Lam, Wendy L, Zhang, Candy T W, Lam, Artemis L, Yan, Ping, Yao, David T W, Lau, Tina T X, Dong, Karl W K, Tsim |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Phytotherapy research : PTR. 28(10) |
| ISSN: |
1099-1573 |
| Popis: |
The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as a health supplement or herbal medicine worldwide. To study the beneficial role of jujube in regulating immune response, we investigated its roles on the expressions of pro-inflammatory cytokines in cultured macrophages. Application of chemically standardized jujube water extract for 24 h stimulated the transcriptional expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in cultured RAW 264.7 macrophages. In contrast, the pretreatment with jujube water extract suppressed the expression of IL-1β and IL-6, but not for TNF-α in lipopolysaccharide (LPS)-stimulated macrophages. The IL-1β and IL-6 cytokines in LPS-induced macrophages were suppressed by jujube water extract in both mRNA and protein levels. In parallel, the inhibition of jujube water extract on the transcriptional activity of nuclear factor-kappa B was revealed in LPS-induced macrophages. These results verified the bidirectional immune-modulatory roles of jujube by regulating the expressions of pro-inflammatory cytokines in macrophages. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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