| Autor: |
Jennifer M, Coughlin, Leah H, Rubin, Yong, Du, Steven P, Rowe, Jeffrey L, Crawford, Hailey B, Rosenthal, Sarah M, Frey, Erica S, Marshall, Laura K, Shinehouse, Allen, Chen, Caroline L, Speck, Yuchuan, Wang, Wojciech G, Lesniak, Il, Minn, Arnold, Bakker, Vidyulata, Kamath, Gwenn S, Smith, Marilyn S, Albert, Babak Behnam, Azad, Robert F, Dannals, Andrew, Horti, Dean F, Wong, Martin G, Pomper |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
J Nucl Med |
| ISSN: |
1535-5667 |
| Popis: |
Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer’s disease. (18)F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-(18)F-fluorodibenzo[b,d]thiophene 5,5-dioxide) is a radioligand for estimating the availability of α7-nAChR in the brain in vivo with PET. Methods: In this cross-sectional study, 14 patients with mild cognitive impairment (MCI), a prodromal stage to dementia, and 17 cognitively intact, elderly controls completed (18)F-ASEM PET. For each participant, binding in each region of interest was estimated using Logan graphical analysis with a metabolite-corrected arterial input function. Results: Higher (18)F-ASEM binding was observed in MCI patients than in controls across all regions, supporting higher availability of α7-nAChR in MCI. (18)F-ASEM binding was not associated with verbal memory in this small MCI sample. Conclusion: These data support use of (18)F-ASEM PET to examine further the relationship between α7-nAChR availability and MCI. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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