Investigating the antimicrobial, antioxidant and cytotoxic activities of the biological synthesized glutathione selenium nano-incorporation

Autor:	Ahmed I, El-Batal, Yasser M, Ragab, Magdy A, Amin, Ghada M, El-Roubi, Farag M, Mosallam
Rok vydání:	2021
Předmět:	Cell Survival Biphenyl Compounds Antineoplastic Agents Gram-Positive Bacteria Glutathione Antioxidants Anti-Bacterial Agents Selenium Picrates Cell Line Tumor Gram-Negative Bacteria Humans Nanoparticles Drug Screening Assays Antitumor Particle Size Cell Proliferation
Zdroj:	Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 34(4)
ISSN:	1572-8773
Popis:	Aqueous glutathione selenium nano-incorporation (GSH-SeN-Inco) was prepared by gamma radiation in presence of microbial glutathione (GSH) and selenium dioxide. The novel prepared GSH-SeN-Inco are validated by UV-vis spectroscopy, TEM (17.5 nm), DLS, XRD, EDX and FTIR spectrum reveals the presence of GSH moiety that coating the selenium nanoparticles (SeNPs) forming GSH-SeN-Inco. The XRD analysis verified the presence of metallic SeNPs. The nucleation and radiolysis mechanism of GSH-SeN-Inco formation are also discussed. The size GSH-SeN-Inco (17.5 nm) is affected by certain factors such as concentration of GSH, selenium dioxide, and absorbed dose of gamma radiation. The present study explored the positive role of GSH-SeN-Inco as an antitumor activity against HepG-2 and MCF-7, with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1efeb2f6c76a44f3001dc7693db4fc46 https://pubmed.ncbi.nlm.nih.gov/33895912 Zobrazit plný text záznamu Full text from SpringerLink