Enhancement of spontaneous C3H/HeJ mammary tumorigenesis by long-term polyadenylic-polyuridylic acid therapy

Autor: W P, Drake, W J, Pendergrast, R E, Kramer, M R, Mardiney
Rok vydání: 1975
Předmět:
Zdroj: Cancer research. 35(11 Pt 1)
ISSN: 0008-5472
Popis: Female C3H/HeJ mice received weekly s.c. injections of 2 mg polyadenylic-polyuridylic acid. Therapy was initiated at either 2 or 9 months of age. In both cases, poly-adenylic-polyuridylic acid-treated animals developed the spontaneous mammary carcinoma associated with this strain more rapidly. Because the opposite result was formerly observed for AKR spontaneous leukemia, the data indicate the polyadenylic-polyuridylic acid has no generalized antineoplastic effect upon spontaneous tumors genetically associated with specific murine strains.
Databáze: OpenAIRE