In vivo-in vitro correlations with a commercial dissolution simulator. Studies on the H2 receptor antagonist mifentidine

Autor:	D D, Erol, A, Rosen
Rok vydání:	1996
Předmět:	Diffusion Histamine H2 Antagonists Solubility Imidazoles Hydrogen-Ion Concentration Absorption
Zdroj:	Arzneimittel-Forschung. 46(10)
ISSN:	0004-4172
Popis:	The dissolution profile of mifentidine (CAS 83184-43-4), which is used as an antagonist of histamine at H2 receptors, was determined using a dissolution simulator. The use of an absorption simulator, which is designed to provide an estimate of the optimum sampling scheme for the dissolution simulator, provides useful data for this purpose. Various in vivo-in vitro correlations for mifentidine were examined and were found to be good.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1ed8f009e70d9fc0d363131946e81f55 https://pubmed.ncbi.nlm.nih.gov/8931893 Zobrazit plný text záznamu