| Autor: |
V I, Kapel'ko, M S, Gorina, M Iu, Men'shikov, V A, Tkachuk |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny. 100(7) |
| ISSN: |
0365-9615 |
| Popis: |
The calmodulin inhibitor trifluoroperazine (5 microM) diminished the velocity of contraction and relaxation of the guinea-pig papillary muscle by 31 and 53%, respectively. Methophenazine showed approximately the same affinity to both calmodulin and trifluoroperazine and nearly 40-fold less affinity to troponin. Methophenazine (5 microM) did not change the contraction velocity and diminished the relaxation velocity ty 21%. It is suggested that calmodulin participates mainly in the control of myocardial relaxation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
