Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system
Autor: | K W, Culver, J, Van Gilder, C J, Link, T, Carlstrom, T, Buroker, W, Yuh, K, Koch, K, Schabold, S, Doornbas, B, Wetjen |
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Rok vydání: | 1994 |
Předmět: |
Adult
Male Cell Survival Recombinant Fusion Proteins Genetic Vectors Thymidine Kinase Mice Viral Proteins Clinical Protocols Tumor Cells Cultured Animals Humans Simplexvirus Ganciclovir Cells Cultured Injections Spinal Salvage Therapy Informed Consent Brain Neoplasms Genetic Therapy Combined Modality Therapy Rats Mice Inbred C57BL Female Sarcoma Experimental Moloney murine leukemia virus |
Zdroj: | Human gene therapy. 5(3) |
ISSN: | 1043-0342 |
Popis: | Murine retroviral vectors can infect a wide variety of proliferating mammalian cell types (e.g. lymphocytes). Non-proliferating tissues (e.g. neurons) are not transduced by murine retroviral vectors. These findings suggest that this type of vector may be useful for the selective introduction of genes into growing tumors in the brain, since the tumor is essentially the only tissue that will integrate and express the vector genes. |
Databáze: | OpenAIRE |
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