Optical control of neuronal firing
| Autor: | Yuta, Takano, Tomohiro, Numata, Kazuto, Fujishima, Kazuaki, Miyake, Kazuya, Nakao, Wesley David, Grove, Ryuji, Inoue, Mineko, Kengaku, Shigeyoshi, Sakaki, Yasuo, Mori, Tatsuya, Murakami, Hiroshi, Imahori |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6520 |
| Popis: | A rationally designed donor–acceptor conjugate efficiently generates a photoinduced charge-separated state in a cellular environment, achieving photoinduction of neuronal firing. A series of porphyrin–fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light. |
| Databáze: | OpenAIRE |
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