| Autor: |
Joseph, Tsemeugne, Lahngong M, Shinyuy, Sorel K D, Djeukoua, Emmanuel F, Sopbue, Moses N, Ngemenya |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Parasitology research. 120(6) |
| ISSN: |
1432-1955 |
| Popis: |
Control and treatment of onchocerciasis, a devastating tropical filarial disease caused by Onchocerca volvulus, rely solely on the community directed treatment with ivermectin. However, ivermectin is only microfilaricidal with evidence of resistance of the parasite among other limitations, which necessitate the search for new efficacious and safe filaricides. Ten synthetic thienylazoryl dyes were screened in vitro against adult and microfilariae worm stages of Onchocerca ochengi based on worm motility and MTT formazan assay. Cytotoxicity of active compounds was assessed on monkey kidney epithelial cells (LLC-MK2) using the MTT formazan assay. Seven (7) compounds showed both macrofilaricidal activity against adult male worms and microfilaricidal activity among which three 4a, 4c and 4e recorded the highest activity (IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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